Three patent applications of summer of 2024

Three patent applications were published in July, that are all related to what is called concomitant gradient correction. This refers to magnetic field vector components that are unwanted but occurring as a byproduct of the desired magnetic fields in MRI. The three patents each address measurement, hardware-based correction, and software correction. The problem of concomitant field first came to me in early 2000s when I was a graduate student working on microTesla MRI with superconducting sensors. That work was reported here in a JMR article: https://pubmed.ncbi.nlm.nih.gov/19664947/. At that time the issue was too weak a main magnetic field; now the problem is due to too strong a gradient field. Different regime, but the same physics.

Three papers of summer of 2024

I was silent for 3 months! In those summer months, 3 papers of mine came out, in Journal of Applied Physics, IEEE Transactions on Magnetics, and Magnetic Resonance Imaging. They report studies related to, and motivated by, MRI gradient coils. The three papers, respectively, provide a first systematic mathematical formulation of magneto-mechanical coupling, derive a versatile, surface eddy current equation, and describe a practical method to reduce acoustic noise in high-performance MRI. They all center around solving critical engineering problems in high-field, high-gradient MRI, in order to make strong magnetic fields more accessible and exploitable for advanced brain imaging. Apart from the subject matter, a not-so-coincidental feature that is common to all three papers is that they have a non-sectioned, single-paragraph abstract! They are also in journals where authors don't have to pay to publish.

Head-only then and now

In this year's ISMRM meeting, accessibility, Helium-free magnet, and high-performance gradients were at the top of many people's mind. In 2016, GE's 3T head-only scanner already combined all three. The figure above compares the 2019 ISMRM floor (right) showcasing GE's then-latest ESP head-only scanner, with this year's floor in Singapore (left) where MAGNUS 3T was unveiled with much acclaim. ESP didn't pan out; time will tell if MAGNUS will. 

About Low-field: This year's ISMRM was flooded with low-field MRI presentations in all formats. Anyone who was in the MRI field long enough will know that performance is the key. Did the bar go down in the name of democratization? Will AI magically lift the SNR? Or is MRI undergoing a transition from a physics and engineering wonder to commodity electronics? Maybe all of the above. Something good may well come out of this, but I sincerely hope that the trend is guided by unselfish, conflict-free, balanced and broad view of MRI's place in medical imaging. 

Digital posters for ISMRM 2024

 

ISMRM announced proceedings of this year's scientific meeting on its website. The digital posters are now presented as an author-recorded video (in most cases, a power point with narration) in a common wrapper which contains links to section headings. This reduces the video screen size but helps audience keep track of the contents in context. Two such posters of mine are shown in screen captures above. Availability of remote participation was certainly accelerated by the pandemic, and may contribute to lower in-person attendance from regions far away. Good luck with all those who travel to Singapore in May!

DIANA questions, raised scientifically

 A first scientific counterargument against DIANA was published recently in an open-access journal: A different interpretation of the DIANA fMRI signal | Science Advances. The three main points are the following: (1) The authors did reproduce the original MRI data and therefore the original report by Toi et al. in Science is likely true on observed facts. (2) On the other hand, the authors could explain their own observations better without invoking neuronal response, but rather based on instrumental artifacts and coincidental circumstances. (3) Regarding membrane potential-induced T2 change, the authors believe that the originally reported in-vitro T2 change is rather caused by cell swelling than membrane potential. The authors did leave several questions unanswered that need to be answered in order to reconcile their assertion with the large amount of experimental data reported in Toi et al.

It is notable that the authors humbly titled their paper as "A different interpretation of DIANA fMRI" and showed reservation of judgment and desire to be constructive. The paper ends with a respectable remark, "Although the goal of probing neural activity with millisecond temporal resolution using fMRI remains unmet, we hope that the contribution of Toi et al. will inspire further efforts to achieve this ambitious and worthy objective."

The questions raised by this paper are certainly serious and substantial. But they were brought up in a way to allow professional debate and objective mutual verification. I hope this development, along with the growing body of positive data from Prof. Park's team, will soon bring clarity to this tantalizing DIANA puzzle.

Installation finished

Brigham and Women's hospital in Boston now has the latest Magnus gradient system which started to generate beautiful brain images!

[Update] An opening ceremony for the Magnus imaging facility was held on March 28th in a nearby Brigham and Women's hospital building with the senior leadership of the hospital. It was a nice showcase of an exemplary co-work among the government, industry, and academia. It is only the beginning!

[Link] A website (https://brighamandwomens.theopenscholar.com/magnus/) introduces the State government-funded Magnus program.

Installation under way

 

Installation of a brand-new Magnus gradient system is under way in Brigham and Women's hospital in Boston. This was funded by the Massachusetts Life Sciences Center (link to grant news). Prof. Westin, the PI on the right in the picture, indicated that the users will be split half and half between clinical and physics/engineering research. Brigham and Women's hospital has many campuses across the area. The Fenwood location, where the 2023 neuroimaging conference was held, had received the country's second clinical 7T MRI machine from Siemens in 2017. (That's why the name may sound familiar to those involved in the 7T commotion in Korea.)